• Aged between 20 and 90 years old

• Patients diagnosed with metastatic colorectal cancer who is going to receive FOLFIRI chemotherapy

• Female must not be planning to become pregnant or breastfeeding, and not pregnant at any point during treatment. (Contraception is required to participate in this trial)

• Those without major physiological diseases (example of major cardiovascular disease is acute myocardial infarction; example of major cerebrovascular disease is acute stroke, malignant hypertension, acute kidney failure, acute liver failure)

• Those who are not allergic to the relevant drugs required for the test

• Those who can follow the doctor's order to take the medicine

• Subjects must be willing to sign the consent form

• Blood sugar level above 80 mg/dL